کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1377290 981975 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rheological characterization and release properties of inulin-based hydrogels
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Rheological characterization and release properties of inulin-based hydrogels
چکیده انگلیسی

In the present study the rheological properties of hydrogels obtained through UV irradiation of an aqueous solution of methacrylated inulin (INUMA) alone or in the presence of four different crosslinkers, have been recorded as a function of irradiation time, at two different wavelengths (320 and 365 nm) and fixed frequency and amplitude by oscillatory experiments. Each hydrogel has been analyzed by measurements of the frequency-dependency of the elastic modulus, G′, in the linear viscoelastic region. The amount of polymeric chains giving an elastic response has been correlated to the chemical nature of the crosslinker used together with INUMA. Finally the release properties of the hydrogel exhibiting the highest elastic modulus have been tested by using 5-Fluorouracil, as a model drug, and two different loading procedures. The rheological characterization allowed us to determine the most effective condition (appropriate crosslinker, wavelength and irradiation time) to obtain a strong hydrogel that was able to give a modified drug release in simulated gastrointestinal fluids.


► UV irradiation of methacrylated inulin alone or in the presence of crosslinkers.
► Evaluation of mechanical properties of inulin based hydrogels.
► Effect of crosslinker, irradiation time and wavelength on elastic modulus.
► Drug loading before or after UV irradiation.
► Evaluation of drug release in simulated gastrointestinal fluids.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 88, Issue 3, 15 April 2012, Pages 1033–1040
نویسندگان
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