کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1383168 1500621 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development and physicochemical characterization of alginate composite film loaded with simvastatin as a potential wound dressing
ترجمه فارسی عنوان
مشخصه های توسعه و بررسی فیزیکوشیمیایی فیلم کامپوزیت آلژینات با سیمواستاتین به عنوان یک پوشش پانسمان زخم
کلمات کلیدی
پانسمان زالو فیلم، فیلم کامپوزیت آلژینات، پکتین، سیمواستاتین
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

Previously, studies have demonstrated that topical application of simvastatin can promote wound healing in diabetic mice via augmentation of angiogenesis and lymphangiogenesis. This study aimed to formulate and characterize simvastatin in alginate-based composite film wound dressings. Biopolymers used for composite films were sodium alginate blended with pectin or gelatin. The films were prepared and characterized based on their physical properties, surface morphology, mechanical strength and rheology. Then, in vitro drug releases from the films were investigated and, finally, the cell viability assay was performed to assess the cytotoxicity profile. From the pre-formulation studies, alginate/pectin composite film showed to possess desirable wound dressing properties and superior mechanical properties. The in vitro drug release profile revealed that alginate/pectin film produced a controlled release drug profile, and cell viability assay showed that the film was non-toxic. In summary, alginate/pectin composite film is suitable to be formulated with simvastatin as a potential wound dressing.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 137, 10 February 2016, Pages 295–304
نویسندگان
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