Surface characterisation of oxygen plasma treated electrospun polyurethane fibres and their interaction with red blood cells

In this work, the effects of oxygen plasma surface modification have been studied on electrospun polyether-based polyurethane in order to investigate the imposed limitations and possibilities to improve surface characteristics on fibrous assemblies. The evolution of induced changes in surface morphology, chemistry and wettability by the plasma treatment has been characterised for increasing plasma exposure time using scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS) and water contact angle measurements. Significant reduction in fibre diameter concomitant with progressing rough surface textures are found on the fibres in surface layers during early treatment phases while extended exposure eventually causes the fibre structure to deteriorate. Surface oxygen content and functionalities such as carbonyl and carboxyl increase slightly with longer treatments until loss of material integrity occurs. The results have also shown that oxygen plasma rapidly alters the initially strong hydrophobic character of the non-woven fibres to hydrophilic behaviour, allowing water penetration into the network, but without significant changes for increased exposure time. In addition, the response of red blood cell shape to pristine and oxygen plasma treated fibres were found to be similar. In both cases, a population of cells having fibre contact displayed protrusions while measurements showed that the cell function remain intact and indicated that the adhesion was non-specific. The reported findings yield useful process knowledge that can support the formation of well-defined fibre architectures and are valuable in the designs of electrospun polyurethane material systems utilising oxygen plasma surface modification.

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► Effects of oxygen plasma on electrospun PU fibres as a function of treatment time.
► Reduce fibre diameter, increase fibre surface roughness and network porosity.
► Surface oxygen functionalities increase slightly while main fibre structure persists.
► Wettability increase dramatically.
► Red blood cell response similar on pristine and oxygen plasma treated fibres.