کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1403643 1501806 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Two polymorphs of 8-hydroxycarbostyril: X-ray crystallography, solid-state NMR and DFT calculations
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Two polymorphs of 8-hydroxycarbostyril: X-ray crystallography, solid-state NMR and DFT calculations
چکیده انگلیسی

Experimental (NMR, X-ray and DSC) and theoretical studies [DFT B3LYP/6-311++G (d,p)] have permitted to establish the structure of the main tautomeric form of 8-hydroxycarbostyril 1. In the gas phase two tautomers, 8-hydroxyquinolin-2(1H)-one 1a and 2,8-quinolinediol 1d, show similar stabilities. In solid state two polymorphs of 1a have been isolated and their structures elucidated, polymorph A which crystallizes in Pccn orthorhombic space group and polymorph B in the P21/c monoclinic space group. The arrangement of molecules in both structures is characterized by intermolecular N–H⋯O and O–H⋯O hydrogen bonds.


► Gas phase stabilities for all forms of 8-hydroxycarbostyril are calculated.
► In solid and solution 8-hydroxycarbostyril exists as 8-hydroxyquinolin-2(1H)-one.
► Two polymorphs of 8-hydroxyquinolin-2(1H)-one have been isolated and characterized.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 1008, 25 January 2012, Pages 88–94
نویسندگان
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