کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1403773 | 1501811 | 2011 | 11 صفحه PDF | دانلود رایگان |

New 2-oxosparteine derivatives with alkyl (n-propyl-, n-pentyl-, n-hexyl- and n-heptyl-) substituent at C-17 position have been synthesized and studied by 1H, 13C NMR, MS, FT-IR and theoretical methods. It has been shown that alkyl substituent introduced at C-17 position is equatorially oriented and does not change the boat conformation of ring C. All newly obtained derivatives, when treated with HClO4 give only monoperchlorate salts.
► NMR spectra of new 17-alkyllupanine derivatives and their perchlorates.
► EI-MS and ESI-MS mass spectral behaviour of 17-alkyl substituted lupanines.
► According to DFT calculations boat–chair conformation is energetically favourable.
► All compound gives only monoperchlorate salts with protonated nitrogen atom N-16.
Journal: Journal of Molecular Structure - Volume 1003, Issues 1–3, 28 September 2011, Pages 10–20