کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | ترجمه فارسی | نسخه تمام متن |
---|---|---|---|---|---|
1404899 | 1501726 | 2015 | 7 صفحه PDF | سفارش دهید | دانلود رایگان |

• We synthesized a series of mono- and bis-Mannich base hydrochlorides and of 3-keto-1,5-bisphosphonates.
• We characterized the synthesis compounds on the basis of their infrared (IR), 1H, 13C and 31P NMR spectral data.
• All the title compounds were tested for their in vitro antioxidant activities as well as their chelating abilities.
• We tried to analyze the pro-oxidant capacity of compounds.
• All the tested compounds showed significant antioxidant activity and high ProAntidex.
A series of mono- and bis-Mannich base hydrochlorides and of 3-keto-1,5-bisphosphonates were prepared and characterized on the basis of their infrared (IR), 1H, 13C and 31P NMR spectral data. All the title compounds were tested for their in vitro antioxidant activities by 1,1-diphenyl-2-picrylhydrazyl (DPPH), H2O2, hydroxyl radical and Ferric Reducing Power (FRP) methods. The antioxidant activity of these compounds was analyzed simultaneously with their pro-oxidant capacity. The ratio of pro-oxidant to the antioxidant activity (ProAntidex) represents a useful index of the net free radical scavenging potential of the synthesized compounds. Ferrous, calcium and magnesium ion chelating abilities were also evaluated. All the tested compounds showed significant antioxidant activity and high ProAntidex.
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Journal: Journal of Molecular Structure - Volume 1091, 5 July 2015, Pages 152–158