Structure-based virtual screening and biological evaluation of LuxT inhibitors for targeting quorum sensing through an in vitro biofilm formation

LuxT informs the readers of bacteriology as novel drug target and this study deals with specificity of potent lead compounds and justify the requirements of LuxT for inhibition of Quorum sensing. This study is a combo of experimental and theoretical, which suggest that the screened compounds had better efficacy in biofilm destruction; as a consequence, there were significant effects on motility and EPS synthesis.