کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1423596 1509027 2016 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
pH-responsive polymer–drug conjugates: Design and progress
ترجمه فارسی عنوان
پلاژیوم واکنش پذیر پلی مراز: طراحی و پیشرفت
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی

Polymer–drug conjugates are becoming established as a shining platform for drug delivery. Incorporation of pH-responsive linker between drug and polymer is expected to realize triggered release of bioactive agents from conjugates in specific sites, either in mildly acidic extracellular matrices of tumor tissues or, after cellular internalization, in acidic endosomes and lysosomes. As an emerging drug delivery system, such pH-responsive polymer–drug conjugates are able to selectively deliver and activate drug molecules while reducing their systemic side-effects. In this review, we present the recent advances in pH-responsive polymer–drug conjugates with different chemical structures and architectures, and attempt to clarify their mechanism of action, synthesis and characterization technology. Furthermore, several promising approaches for the future will also be suggested.

The different structures and advantages of pH-responsive polymer–drug conjugates.Figure optionsDownload high-quality image (240 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 222, 28 January 2016, Pages 116–129
نویسندگان
, , , , , ,