کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1424416 986722 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reductionism and complexity in nanoparticle-vectored drug targeting
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Reductionism and complexity in nanoparticle-vectored drug targeting
چکیده انگلیسی

This paper briefly discusses reductionism as a process for dissecting the complexities of drug targeting mediated by nanoparticulate carriers. While reductionism has been said to have been a drawback to enhanced appreciation and understanding of complex biological systems, it is concluded here that the dissection of the individual stages of the procession from injection to final destination in specific targets in a living complex organism is essential. It should allow a decrease in the empiricism from laudable and inventive efforts to achieve high levels of drug delivery to specific diseased targets such as tumours. At the stage of development of the field there have perhaps been fewer than desirable detailed experimental or theoretical investigations of these individual stages. However, there are frequently analogies in the literature from which to draw at least tentative conclusions about the physics, physical chemistry and biology which underpin the processes involved.

Figure optionsDownload high-quality image (356 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 161, Issue 2, 20 July 2012, Pages 399–402
نویسندگان
,