کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1424439 986722 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microneedle technologies for (trans)dermal drug and vaccine delivery
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Microneedle technologies for (trans)dermal drug and vaccine delivery
چکیده انگلیسی

Microneedles have been used for the dermal and transdermal delivery of a broad range of drugs, such as small molecular weight drugs, oligonucleotides, DNA, peptides, proteins and inactivated viruses. However, until now there are no microneedle-based (trans)dermal drug delivery systems on the market. In the past decade various types of microneedles have been developed by a number of production processes. Numerous geometries of microneedles have been designed from various materials. These microneedles have been used for different approaches of microneedle-based (trans)dermal drug delivery. Following a brief introduction about dermal and transdermal drug delivery, this review describes different production methods for solid and hollow microneedles as well as conditions that influence skin penetration. Besides, the four microneedle-based (trans)dermal drug delivery approaches are discussed: “poke and flow”, “poke and patch”, “poke and release”, and “coat and poke”. A separate section of this review is devoted to the use of microneedles for the delivery of therapeutic proteins and vaccines. Finally, we give our view on research and development that is needed to render microneedle-based (trans)dermal drug delivery technologies clinically useful in the near future.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 161, Issue 2, 20 July 2012, Pages 645–655
نویسندگان
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