کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1717190 | 1520029 | 2007 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Haploid deletion strains of Saccharomyces cerevisiae that determine survival during space flight
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موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی هوافضا
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چکیده انگلیسی
This study identifies genes that determine survival during a space flight, using the model eukaryotic organism, Saccharomyces cerevisiae. Select strains of a haploid yeast deletion series grew during storage in distilled water in space, but not in ground based static or clinorotation controls. The survival advantages in space in distilled water include a 133-fold advantage for the deletion of PEX19, a chaperone and import receptor for newly- synthesized class I peroxisomal membrane proteins, to 77-40 fold for deletion strains lacking elements of aerobic respiration, isocitrate metabolism, and mitochondrial electron transport. Following automated addition of rich growth media, the space flight was associated with a marked survival advantage of strains with deletions in catalytically active genes including hydrolases, oxidoreductases and transferases. When compared to static controls, space flight was associated with a marked survival disadvantage of deletion strains lacking transporter, antioxidant and catalytic activity. This study identifies yeast deletion strains with a survival advantage during storage in distilled water and space flight, and amplifies our understanding of the genes critical for survival in space.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Astronautica - Volume 60, Issues 4â7, FebruaryâApril 2007, Pages 460-471
Journal: Acta Astronautica - Volume 60, Issues 4â7, FebruaryâApril 2007, Pages 460-471
نویسندگان
Kelly Johanson, Patricia L. Allen, Romer A. Gonzalez-Villalobos, Jacqueline Nesbit, Cheryl A. Nickerson, Kerstin Höner zu Bentrup, James W. Wilson, Rajee Ramamurthy, Riccardo D'Elia, Kenneth E. Muse, Jeffrey Hammond, Jake Freeman, Louis S. Stodieck,