کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1761038 | 1019631 | 2011 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Advanced Characterization and Refinement of Poly N-Butyl Cyanoacrylate Microbubbles for Ultrasound Imaging
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Advanced Characterization and Refinement of Poly N-Butyl Cyanoacrylate Microbubbles for Ultrasound Imaging Advanced Characterization and Refinement of Poly N-Butyl Cyanoacrylate Microbubbles for Ultrasound Imaging](/preview/png/1761038.png)
چکیده انگلیسی
We aimed to develop and characterize poly n-butylcyanoacrylate (PBCA) microbubbles (MBs) with a narrow size distribution. MBs were synthesized by established emulsion polymerization techniques, size-isolated by centrifugation and functionalized for molecular imaging by coating their surface with streptavidin. The physical and acoustic properties of the parent solution, different-size isolated populations and functionalized MBs were measured and compared. As expected from negative zeta potentials at pH 7, cryo scanning electron microscopy showed no aggregates. In phantoms MBs were destructible at high mechanical indices and showed a frequency-dependent attenuation and backscattering. The MBs were stable in solution for more than 14 weeks and could be lyophilized without major damage. However, for injection, small needle diameters and high injection rates are shown to be critical because both lead to MB destruction. In summary, when being handled correctly, size-isolated PBCA MBs are promising candidates for preclinical functional and molecular ultrasound imaging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 37, Issue 10, October 2011, Pages 1622-1634
Journal: Ultrasound in Medicine & Biology - Volume 37, Issue 10, October 2011, Pages 1622-1634
نویسندگان
Stanley Fokong, Monica Siepmann, Zhe Liu, Georg Schmitz, Fabian Kiessling, Jessica Gätjens,