The AMERE project: Enabling real-time detection of radiation effects in individual cells in deep space

A major concern for long-term deep space missions is the detrimental impact of cosmic radiation on human health. Especially the presence of high-energy particles of high atomic mass (HZE) represents a serious threat. To contribute to a fundamental understanding of space radiation effects and to help improving risk assessment for humans on the Moon, the ESA Lunar Lander mission model payload includes a package dedicated to cell-based radiobiology experiments in the form of an Autonomous Microscope for Examination of Radiation Effects (AMERE). The purpose of this setup is to enable real-time visualization of DNA damage repair in living cells after traversal of HZE particles on the Moon. To assess the feasibility of this challenging experiment, we have analysed the biological and technological demands. In this article, we discuss the experimental concept, the biological considerations and describe the implications for system design.

► High-energy particles of high atomic mass are a health hazard for deep space travel.
► Visualization of DNA damage repair in living cells will improve space biodosimetry.
► We examined the feasibility of this concept and identified major requirements.
► A fully autonomous microscope demands online intelligence and robotic interaction.
► Keeping cells in good condition demands conservation and environmental control.