کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1904750 1534657 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Abeta, oxidative stress in Alzheimer disease: Evidence based on proteomics studies
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Abeta, oxidative stress in Alzheimer disease: Evidence based on proteomics studies
چکیده انگلیسی


• Alzheimer disease (AD), amyloid-β processing, and ROS implicated in AD are examined.
• The Aβ peptide induced oxidative stress hypothesis of AD is discussed.
• Met-35 of amyloid-β peptide and its role in oxidative stress in AD are discussed.
• An overview of redox proteomics and applications to AD and AD models is presented.
• Antioxidant treatment and biomarker research relevant to AD are presented.

The initiation and progression of Alzheimer disease (AD) is a complex process not yet fully understood. While many hypotheses have been provided as to the cause of the disease, the exact mechanisms remain elusive and difficult to verify. Proteomic applications in disease models of AD have provided valuable insights into the molecular basis of this disorder, demonstrating that on a protein level, disease progression impacts numerous cellular processes such as energy production, cellular structure, signal transduction, synaptic function, mitochondrial function, cell cycle progression, and proteasome function. Each of these cellular functions contributes to the overall health of the cell, and the dysregulation of one or more could contribute to the pathology and clinical presentation in AD. In this review, foci reside primarily on the amyloid β-peptide (Aβ) induced oxidative stress hypothesis and the proteomic studies that have been conducted by our laboratory and others that contribute to the overall understanding of this devastating neurodegenerative disease. This article is part of a Special Issue entitled: Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1842, Issue 8, August 2014, Pages 1248–1257
نویسندگان
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