کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1904995 1534683 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats
چکیده انگلیسی

Hypoxia inducible factor (HIF)-1α-mediated gene activation in the renal medulla in response to high salt intake plays an important role in the control of salt sensitivity of blood pressure. High salt-induced activation of HIF-1α in the renal medulla is blunted in Dahl S rats. The present study determined whether the impairment of the renal medullary HIF-1α pathway was responsible for salt sensitive hypertension in Dahl S rats. Renal medullary HIF-1α levels were induced by either transfection of HIF-1α expression plasmid or chronic infusion of CoCl2 into the renal medulla, which was accompanied by increased expressions of anti-hypertensive genes, cyclooxygenase-2 and heme oxygenase-1. Overexpression of HIF-1α transgenes in the renal medulla enhanced the pressure natriuresis, promoted the sodium excretion and reduced sodium retention after salt overload. As a result, hypertension induced by 2-week high salt was significantly attenuated in rats treated with HIF-1α plasmid or CoCl2. These results suggest that an abnormal HIF-1α in the renal medulla may represent a novel mechanism mediating salt-sensitive hypertension in Dahl S rats and that induction of HIF-1α levels in the renal medulla could be a therapeutic approach for the treatment of salt-sensitive hypertension.


► High salt-induced HIF-1α activation in the renal medulla is blunted in Dahl S rat.
► Induction of HIF-1α increased the expressions of anti-hypertensive genes.
► Induction of HIF-1α in the renal medulla enhanced sodium excretion.
► Induction of HIF-1α in the renal medulla attenuated salt-sensitive hypertension.
► Abnormal HIF-1α in the renal medulla is the cause for salt-sensitive hypertension.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1822, Issue 6, June 2012, Pages 936–941
نویسندگان
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