کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1927644 | 1536534 | 2006 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Pro-apoptotic effect of maize lipid transfer protein on mammalian mitochondria Pro-apoptotic effect of maize lipid transfer protein on mammalian mitochondria](/preview/png/1927644.png)
To assess the effect of lipids and lipid exchange in the pro-apoptotic release of cytochrome c, we investigated the ability of a plant lipid transfer protein (LTP) to initiate the apoptotic cascade at the mitochondrial level. The results show that maize LTP is able to induce cytochrome c release from the intermembrane space of mouse liver mitochondria without significant mitochondrial swelling, similarly to mouse full-length Bid. This effect is influenced by the presence of specific lipids, since addition of lysolipids like lysophosphatidylcholine strongly stimulates the LTP-induced release of cytochrome c while it is inhibited by removal of endogenous free lipids with a complete suppression of the LTP-induced release of cytochrome c. The results are discussed in light of the possible role of lipid exchange in apoptosis.
Journal: Archives of Biochemistry and Biophysics - Volume 445, Issue 1, 1 January 2006, Pages 65–71