Octaarginine-modified liposomes enhance the anti-oxidant effect of Lecithinized superoxide dismutase by increasing its cellular uptake

► In this study we succeeded in developing an octaarginine modified liposome equipped with PC-SOD (R8-LP (PC-SOD)). ► R8-LP (PC-SOD) was taken up by cells more efficiently than PC-SOD. ► R8-LP (PC-SOD) has the ability to deliver PC-SOD to the cytosol efficiently. ► R8-LP (PC-SOD) was scavenged superoxide anions (O2-) very efficiently. ► The efficient cytosolic delivery by R8-LP enhances the anti-oxidant effect of PC-SOD.