کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1931007 1050536 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins
چکیده انگلیسی

The roles of T lymphocytes in the central nervous system (CNS) are diverse; their roles in the injured CNS have been reported to be both detrimental and advantageous. Hence, an investigation of the effects of specific subsets of T cells on neurons may provide an insight into the interaction between the nervous system and the immune system. In the present study, we demonstrate that a specific subset of T lymphocytes enhanced neurite outgrowth in vitro. When cultured T helper type 1 (Th1) cells were co-cultured with cortical neurons, neurite outgrowth from neurons was enhanced; however, the same was not observed when Th2 or naïve T cells were used. We observed that the promotion of neurite outgrowth by Th1 cells was completely inhibited by anti-interferon γ (IFN-γ) neutralizing antibody, but that IFN-γ did not directly promote neurite growth. Furthermore, experiments using knockout mice revealed that semaphorin 4A (Sema4A) but not Sema7A was required for the effect produced by Th1 cells. These results demonstrate that Sema4A and IFN-γ expressed in Th1 cells play a critical role in enhancing neurite outgrowth from cortical neurons.

Research highlights
► Interaction of helper T cells and neurons.
► Th1 cells promote neurite growth.
► Sema4A and IFN-γ play critical roles in inducing neurite growth.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 402, Issue 1, 5 November 2010, Pages 168–172
نویسندگان
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