کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1931354 | 1536787 | 2010 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cyclic adenosine monophosphate induces plasminogen activator inhibitor-1 expression in human mast cells Cyclic adenosine monophosphate induces plasminogen activator inhibitor-1 expression in human mast cells](/preview/png/1931354.png)
Plaminogen activator inhibitor-1 (PAI-1), the key physiological inhibitor of the plasmin fibrinolytic system, plays important roles in the pathogenesis of asthma. Mast cells (MCs) are crucial effector cells and a major source of PAI-1 for asthma. Cyclic adenosine monophosphate (cAMP) is the important regulator of MCs; however, its effects on PAI-1 expression in MCs remain unknown. We reported cAMP/protein kinase A pathway positively regulates PAI-1 expression through cAMP-response element binding protein binding to hypoxia response element-1 at −158 to −153 bp of human PAI-1 promoter in human MCs. Moreover, cAMP synergistically augments PAI-1 expression with ionomycin- or IgE receptor cross-linking-mediated stimulation.
Research highlights
► Cyclic AMP induces plasminogen activator inhibitor-1 (PAI-1) expression in mast cells (MCs).
► The cAMP-response element-binding protein is the key transcription factor.
► The hypoxia response element-1 at −158/−153 bp is the pivotal cis-acting element.
► Cyclic AMP synergistically augments PAI-1 expression in ionomycin- or IgE-stimulated MCs.
Journal: Biochemical and Biophysical Research Communications - Volume 400, Issue 4, 1 October 2010, Pages 569–574