کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1932453 | 1050582 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of acrolein-conjugated protein in plasma of patients with brain infarction
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
It is known that the level of protein-conjugated acrolein in plasma is a good marker of chronic renal failure and brain infarction. Thus, studies were carried out to determine which kinds of plasma proteins are conjugated with acrolein. It was found that acrolein was mainly conjugated with albumin. Tandem mass spectrometry analysis demonstrated that Lys-557 and Lys-560, located at the surface of domain III of albumin, were the major sites conjugated with acrolein. This is the first report to identify the amino acid residues in a protein modified by acrolein in vivo. It was found that conjugation of acrolein with albumin contributed to a decrease in the toxicity of acrolein.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 391, Issue 2, 8 January 2010, Pages 1234–1239
Journal: Biochemical and Biophysical Research Communications - Volume 391, Issue 2, 8 January 2010, Pages 1234–1239
نویسندگان
Madoka Yoshida, Kyohei Higashi, Lihua Jin, Yoshiki Machi, Takehiro Suzuki, Akiko Masuda, Naoshi Dohmae, Akiko Suganami, Yutaka Tamura, Kazuhiro Nishimura, Toshihiko Toida, Hideyuki Tomitori, Keiko Kashiwagi, Kazuei Igarashi,