کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1932891 | 1050596 | 2009 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: DcR3 protects THP-1 macrophages from apoptosis by increasing integrin α4 DcR3 protects THP-1 macrophages from apoptosis by increasing integrin α4](/preview/png/1932891.png)
In order to analyze the function of DcR3 for the regulation of cell adhesion and apoptosis in macrophages, we investigated the expression of decoy receptor 3 (DcR3) in THP-1 monocytes/macrophages.DcR3 was expressed in THP-1 and increased by phorbol 12-myristate 13-acetate (PMA). The formation of macrophage aggregates was observed when THP-1 cells were differentiated by PMA or stimulated with DcR3-Fc. Undifferentiated THP-1 cells were also induced to form aggregates by DcR3-Fc. The expression of integrin α4 was significantly increased by DcR3-Fc. CHX-induced apoptosis in THP-1 was inhibited by DcR3-Fc, of which inhibition against CHX-induced apoptosis and aggregate formation were ameliorated by anti-VLA4 antibody.DcR3 may play a significant role in macrophages not only by a decoy receptor but also by increasing α4 integrin.
Journal: Biochemical and Biophysical Research Communications - Volume 389, Issue 4, 27 November 2009, Pages 593–598