کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1933647 | 1050620 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxytocin deficiency impairs maternal skeletal remodeling
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We have reported that the posterior pituitary hormone, oxytocin (OT), known for its effects in inducing parturition, lactation and social bonding, is also a skeletal hormone. Here, we demonstrate that OT plays a key role in enabling maternal skeletal mobilization during pregnancy by enhancing the formation of bone resorbing osteoclasts. Osteoclast formation ex vivo is thus diminished in pregnant mothers with genetic OT-deficiency. OT−/− pups at day E20 also show a defect in trabecular bone. μCT measurements reveal normal bone volume, but increased trabecular numbers, suggesting that trabeculae in OT−/− pups are hypomineralized. We suggest that OT facilitates intergenerational transfer of calcium ions from a pregnant mother to the pups.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 388, Issue 1, 9 October 2009, Pages 161–166
Journal: Biochemical and Biophysical Research Communications - Volume 388, Issue 1, 9 October 2009, Pages 161–166
نویسندگان
Xuan Liu, Kengo Shimono, Ling-Ling Zhu, Jianhua Li, Yuanzhen Peng, Aliza Imam, Jameel Iqbal, Surinder Moonga, Graziana Colaianni, Cai Su, Zuhong Lu, Masahiro Iwamoto, Maurizio Pacifici, Alberta Zallone, Li Sun, Mone Zaidi,