کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1934611 | 1050645 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effects of A. senticosus supplementation on serum lipid profiles, biomarkers of oxidative stress, and lymphocyte DNA damage in postmenopausal women
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study examined the effects of Acanthopanax senticosus supplementation on serum lipid profiles, biomarkers of oxidative stress, and lymphocyte DNA damage in postmenopausal women. Forty postmenopausal women, ages 40-65, were randomly divided into two groups: (1) control group (calcium) and (2) treatment group (calcium plus A. senticosus). Both groups were treated for 6 months. Blood samples were obtained before and after supplementation at 6 months. The following blood parameters were measured: serum total cholesterol, triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), serum malondialdehyde (MDA), ccdd protein-carbonyl (PC) levels, the degree of lymphocyte DNA damage by comet assay, total ferric reducing antioxidant power (FRAP), uric acid, and total bilirubin in serum. The treatment group had significant decreases (p < 0.001) in serum LDL (127.54 ± 29.79 mg/dL vs 110.33 ± 22.26 mg/dL) and the LDL/HDL ratio (2.40 ± 0.65 vs 2.11 ± 0.58) after A. senticosus supplementation. Serum MDA concentrations decreased by 2.2% in the control group and by 12.61% in the treatment group after 6 months of intervention; however, the reductions were not significant in either group. Protein-carbonyl levels and lymphocyte DNA damage decreased significantly (p < 0.001 and p < 0.05, respectively) after 6 months of A. senticosus supplementation. These results suggest that A. senticosus supplementation may have beneficial effects against oxidative stress and improve serum lipid profiles without subsequent side effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 375, Issue 1, 10 October 2008, Pages 44-48
Journal: Biochemical and Biophysical Research Communications - Volume 375, Issue 1, 10 October 2008, Pages 44-48
نویسندگان
Young Jin Lee, Ho-Yeon Chung, Ho-Kyung Kwak, Sun Yoon,