کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1936667 1050699 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen
چکیده انگلیسی

Using RNA interference (RNAi) to suppress gene expression, we attempted to identify tyrosine kinases involved in the extension of neurites from SH-SY5Y cells. A comprehensive analysis of gene “knock-down” profiles with small interfering RNAs (siRNAs) revealed candidate proteins that might control neurite extension. Phenotype-based screening of differentiating SH-SY5Y cells following retinoic acid (RA) stimulation indicated that twinfilin-2 is a protein that is involved in neurite outgrowth, as confirmed by morphological analysis of twinfilin-2-overexpressing cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 363, Issue 4, 30 November 2007, Pages 926–930
نویسندگان
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