کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1936923 1050705 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes
چکیده انگلیسی

Aging is associated with increased fat mass and decreased lean mass, which is strongly associated with the development of insulin resistance. Gastric inhibitory polypeptide (GIP) is known to promote efficient storage of ingested nutrients into adipose tissue; we examined aging-associated changes in body composition using 10-week-old and 50-week-old wild-type (WT) and GIP receptor knockout (Gipr−/−) mice on a normal diet, which show no difference in body weight. We found that Gipr−/− mice showed significantly reduced fat mass without reduction of lean mass or food intake, while WT mice showed increased fat mass and decreased lean mass associated with aging. Moreover, aged Gipr−/− mice showed improved insulin sensitivity, which is associated with amelioration in glucose tolerance, higher plasma adiponectin levels, and increased spontaneous physical activity. We therefore conclude that genetic inactivation of GIP signaling can prevent the development of aging-associated insulin resistance through body composition changes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 364, Issue 1, 7 December 2007, Pages 175–180
نویسندگان
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