کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1938355 | 1050738 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The nuclear localization signal of mitotic kinesin-like protein Mklp-1: Effect on Mklp-1 function during cytokinesis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The nuclear localization signal of mitotic kinesin-like protein Mklp-1: Effect on Mklp-1 function during cytokinesis The nuclear localization signal of mitotic kinesin-like protein Mklp-1: Effect on Mklp-1 function during cytokinesis](/preview/png/1938355.png)
چکیده انگلیسی
The mitotic kinesin-like protein (Mklp-1) localizes in the nucleus during interphase due to the presence of nuclear localization signal(s) [NLS(s)] within its sequence. Here, we mapped two NLSs to be 899SRKRRSST906 and 949KRKKP953 in the tail domain of Mklp-1, and showed that ectopic expression of a mutant Mklp-1 without the NLSs leads to cell cycle arrest at cytokinesis, indicating that the NLSs are necessary for Mklp-1 to execute its normal function during cell division. Furthermore, mutation of two serine residues in the first NLS to aspartic acid, which mimics phosphorylation, attenuated its nuclear localization function, suggesting that the function of this NLS might be regulated by phosphorylation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 353, Issue 4, 23 February 2007, Pages 960–964
Journal: Biochemical and Biophysical Research Communications - Volume 353, Issue 4, 23 February 2007, Pages 960–964
نویسندگان
Xiaoqi Liu, Raymond L. Erikson,