کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1940788 | 1050788 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of heparin and dendrimers on the aggregation of two amyloid peptides related to Alzheimer’s and prion diseases
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Amyloid plaques composed of proteinaceous aggregates are commonly found in brains affected by Alzheimer’s disease and spongiform encephalopaties. A structural homology has been recently described for the Alzheimer’s peptide Aβ1–28 and the segment of the prion protein Prp185–208. In the present paper, further elements in common are reported: the aggregation processes are in both cases enhanced by the model glucosaminoglycan heparin and dendrimers can modulate the aggregation process by affecting the nucleation rate at low concentrations and the elongation rate at high concentrations. Nucleation and elongation rate constants are derived from fittings to a nucleation dependent polymerization model.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 339, Issue 2, 13 January 2006, Pages 577–582
Journal: Biochemical and Biophysical Research Communications - Volume 339, Issue 2, 13 January 2006, Pages 577–582
نویسندگان
Barbara Klajnert, Marta Cortijo-Arellano, Maria Bryszewska, Josep Cladera,