کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1940847 1050789 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of ETS transcription factors in transcription and development of mouse preimplantation embryos
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The role of ETS transcription factors in transcription and development of mouse preimplantation embryos
چکیده انگلیسی

Embryonic transcription is a crucial process for the creation of new life. To clarify the mechanism of embryonic transcription, we investigated the expression and function of the erythroblast transformation specific (ETS) domain containing transcription factors (TFs) during preimplantation development in mice. The expression levels of several ETS TFs, i.e., etsrp71, elf3, and spic, increased after fertilization and remained at a high level until the blastocyst stage. To clarify the function of these TFs, we performed gene suppression using RNA interference, which revealed that they were involved in regulating development to the blastocyst stage. Furthermore, we found that suppression of ETS TFs affected the transcription of eIF-1A and oct3/4 genes whose expression is regulated by TATA-less promoters in the embryos. These results suggest that ETS TFs function in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 344, Issue 2, 2 June 2006, Pages 675–679
نویسندگان
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