Mechanism of structural transformations induced by antimicrobial peptides in lipid membranes

►Direct visualization of membrane structural transformations induced by PG-1 via AFM. ►Structural transformations: edge instability -> pores -> wormlike micelles. ►Simulation work shows PG-1 lowering line tension at DMPC bilayer ribbon edges. ►Disruption process understood via a lipid/line-active peptide mesophase framework.