کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1950267 | 1537818 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
NF-κB independent inhibition of lipopolysaccharide-induced cyclooxygenase by a conjugated linoleic acid cognate, conjugated nonadecadienoic acid
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کلمات کلیدی
CLA, conjugated linoleic acid - CLA، اسید لینولئیک کانژوگهCOX-2, cyclooxygenase-2 - COX-2، cyclooxygenase-2DMEM, Dulbecco's Modified Eagle's Medium - DMEM، مدول اصلاح شده عقاب DulbeccoEIA, enzyme immunoassay - EIA، آنزیم ایمونواسیERK, extracellular signal-related kinase - ERK، kinase مرتبط با سیگنال خارج سلولیFBS, fetal bovine serum - سرم جنینی گاوی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: NF-κB independent inhibition of lipopolysaccharide-induced cyclooxygenase by a conjugated linoleic acid cognate, conjugated nonadecadienoic acid NF-κB independent inhibition of lipopolysaccharide-induced cyclooxygenase by a conjugated linoleic acid cognate, conjugated nonadecadienoic acid](/preview/png/1950267.png)
چکیده انگلیسی
10t, 12c-CLA was shown to inhibit COX-2 expression through the NF-κB pathway. In the current study, conjugated nonadecadienoic acid (CNA) was shown to decrease inducible COX-2 protein and mRNA and PGE2 release to the similar extent as 10t, 12c-CLA in Raw264.7 macrophage. However, unlike 10t, 12c-CLA, inhibition of COX-2 mRNA/protein by CNA was independent of the NF-κB pathway. The data indicate the regulation of COX-2 by select conjugated fatty acids and hence their anti-inflammatory actions could operate through different signal transduction pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1761, Issue 9, September 2006, Pages 969–972
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1761, Issue 9, September 2006, Pages 969–972
نویسندگان
Guangming Li, Baiyan Dong, Daniel E. Butz, Yeonhwa Park, Michael W. Pariza, Mark E. Cook,