کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1951886 1538408 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hypoxia-inducible factor-1alpha: A promising therapeutic target in endometriosis
ترجمه فارسی عنوان
فاکتور القاء شده با هیپوکسی - الفا: یک هدف درمانی انتزاعی در اندومتریوز است
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• The etiology of endometriosis remains obscure.
• A close relationship between endometriosis and HIF-1α.
• Therapeutic target for endometriosis based on HIF-1α.

Endometriosis is a common gynecologic disease defined as the presence of ectopic endometrial tissues on the ovaries and pelvic peritoneum, and it is a significant cause of pelvic pain, dysmenorrhea and infertility of women in their reproductive age. However, the etiology of endometriosis remains obscure. In recent years, a growing body of evidence validated that hypoxia developed a close relationship with endometriosis and the expression of hypoxia-inducible factor-1alpha (HIF-1α) was increased significantly in the development of endometriosis. Furthermore, inhibiting the expression of HIF-1α contributed to suppress endometriosis progression, suggesting HIF-1α plays a critical function in endometriosis. Nevertheless, the mechanisms by which HIF-1α associates with endometriosis are still undefined. In this brief review, we had a general understanding of HIF-1α firstly, and then we tried to sum up the collective knowledge of HIF-1α in endometriosis. Finally, we will discuss kinds of novel therapeutic approaches to endometriosis based on the functions of HIF-1α.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 123, April 2016, Pages 130–137
نویسندگان
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