کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1953165 1057254 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
P120-Ras GTPase activating protein (RasGAP): A multi-interacting protein in downstream signaling
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
P120-Ras GTPase activating protein (RasGAP): A multi-interacting protein in downstream signaling
چکیده انگلیسی

p120-RasGAP (Ras GTPase activating protein) plays a key role in the regulation of Ras-GTP bound by promoting GTP hydrolysis via its C-terminal catalytic domain. The p120-RasGAP N-terminal part contains two SH2, SH3, PH (pleckstrin homology) and CaLB/C2 (calcium-dependent phospholipid-binding domain) domains. These protein domains allow various functions, such as anti-/pro-apoptosis, proliferation and also cell migration depending of their distinct partners. The p120-RasGAP domain participates in protein–protein interactions with Akt, Aurora or RhoGAP to regulate functions described bellow. Here, we summarize, in angiogenesis and cancer, the various functional roles played by p120-RasGAP domains and their effector partners in downstream signaling.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 91, Issue 3, March 2009, Pages 320–328
نویسندگان
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