کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1981307 | 1061919 | 2009 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The ubiquitin receptor Rad23: At the crossroads of nucleotide excision repair and proteasomal degradation
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کلمات کلیدی
TFIIHtranscription factor II HhHR23UbDUbiquitin binding domainUFDubiquitin-interacting motifUIMUBAUblTTDERADNER - DOWNDUBs - DUB هاtrichothiodystrophy - TrichothiodystrophyGGR - بارER-Associated Degradation - تخریب ER-Associatednucleotide excision repair - تعمیر مجدد نوکلئوتیدیUbiquitin-like domain - دامنه Ubiquitin مانندUbiquitin-associated domain - دامنه مرتبط با UbiquitinCockayne syndrome - سکته Cockayneendoplasmic reticulum - شبکه آندوپلاسمی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A protein that exemplifies the intimate link between the ubiquitin/proteasome system (UPS) and DNA repair is the yeast nucleotide excision repair (NER) protein Rad23 and its human orthologs hHR23A and hHR23B. Rad23, which was originally identified as an important factor involved in the recognition of DNA lesions, also plays a central role in targeting ubiquitylated proteins for proteasomal degradation, an activity that it shares with other ubiquitin receptors like Dsk2 and Ddi1. Although the finding that Rad23 serves as a ubiquitin receptor explains to a large extent its importance in proteasomal degradation, the precise mode of action of Rad23 in NER and the possible link with the UPS is less clear. In this review, we discuss our present knowledge on the functions of Rad23 in protein degradation and DNA repair and speculate on the importance of the dual roles of Rad23 for the cell's ability to cope with stress conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 8, Issue 4, 5 April 2009, Pages 449-460
Journal: DNA Repair - Volume 8, Issue 4, 5 April 2009, Pages 449-460
نویسندگان
Nico P. Dantuma, Christian Heinen, Deborah Hoogstraten,