Lipoma preferred partner is a mechanosensitive protein regulated by nitric oxide in the heart

▸ Lipoma preferred partner (LPP) is highly expressed in the heart, especially in cardiac fibroblasts. ▸ LPP increases in pressure overload hypertrophy but not in myocardial infarction. ▸ LPP may be used as a novel marker for heart failure due to hemodynamic overload. ▸ Inhibition of nitric oxide upregulates LPP, but not other fibroblast proteins. ▸ LPP may play an important role in cardiac homeostasis and heart disease.