کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2023885 1069823 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanism of transcriptional activation by the Myc oncoproteins
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Mechanism of transcriptional activation by the Myc oncoproteins
چکیده انگلیسی

The Myc family proteins are potent oncogenes that can activate and repress a very large number of cellular target genes. The amino terminus of Myc contains a transactivation domain that can recruit a number of nuclear cofactors with diverse activities. Functional studies link transactivation to the ability of Myc to promote normal cell proliferation and for oncogenic transformation. The biochemical mechanism of Myc-mediated transactivation has revealed a wide range of effects on chromatin and basal transcription. This review summarizes recent advances in understanding the function of Myc as a transcriptional activator and the role of this activity in Myc biological activities.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cancer Biology - Volume 16, Issue 4, August 2006, Pages 242–252
نویسندگان
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