Megakaryocyte development is normal in mice with targeted disruption of Tescalcin

► Upregulation of tescalcin gene augments megakaryocyte development in K562 and HEL cells. ► Mice with targeted disruption of tescalcin gene were created. ► Platelet and megakaryocyte numbers are normal in tescalcin-knockout mice. ► Polyploidization and Fli-1 expression in megakaryocytes of tescalcin-knockout mice is normal. ► Tescalcin does not have an essential role in megakaryocyte differentiation in a murine model.