Cyanobacterial biofuel production

The development of new technologies for production of alternative fuel became necessary to circumvent finite petroleum resources, associate rising costs, and environmental concerns due to rising fossil fuel CO2 emissions. Several alternatives have been proposed to develop a sustainable industrial society and reduce greenhouse emissions. The idea of biological conversion of CO2 to fuel and chemicals is receiving increased attention. In particular, the direct conversion of CO2 with solar energy to biofuel by photosynthetic microorganisms such as microalgae and cyanobacteria has several advantages compared to traditional biofuel production from plant biomass. Photosynthetic microorganisms have higher growth rates compared with plants, and the production systems can be based on non-arable land. The advancement of synthetic biology and genetic manipulation has permitted engineering of cyanobacteria to produce non-natural chemicals typically not produced by these organisms in nature. This review addresses recent publications that utilize different approaches involving engineering cyanobacteria for production of high value chemicals including biofuels.

► This review addresses recent publications with different approaches involving engineering cyanobacteria for production of high valuable chemicals including biofuels.
► First, we summarize isobutyraldehyde and isobutanol production from Synechococcus elongatus PCC 7942.
► Second, we summarize n-butanol production from S. elongatus PCC 7942.
► Third, we summarize isoprene production from Synechocystis sp. PCC6803.
► Finally, we summarize fatty acids production from Synechocystis sp. PCC6803.