Development of immunization trials against Pasteurella multocida

• Pasteurellosis is a major respiratory disease for important farm animals caused by Pasteurella multocida.
• Chemotherapeutic treatment is expensive, lengthy, and ineffective.
• Biosecurity precautions may share to diminish the widespread of the pathogen, but cannot control it.
• Almost all types of vaccines were constructed to prevent the pathogen, but none was fully successful.
• A new regimen depending on both killed and live attenuated vaccination demonstrated full potency.

Pasteurellosis is one of the most important respiratory diseases facing economically valuable farm animals such as poultry, rabbit, cattle, goats and pigs. It causes severe economic loss due to its symptoms that range from primary local infection to fatal septicemia. Pasteurella multocida is the responsible pathogen for this contagious disease. Chemotherapeutic treatment of Pasteurella is expensive, lengthy, and ineffective due to the increasing antibiotics resistance of the bacterium, as well as its toxicity to human consumers. Though, biosecurity measures played a role in diminishing the spread of the pathogen, the immunization methods were always the most potent preventive measures. Since the early 1950s, several trials for constructing and formulating effective vaccines were followed. This up-to-date review classifies and documents such trials. A section is devoted to discussing each group benefits and defects.