کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2402803 1102853 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prospective epidemiologic surveillance of invasive pneumococcal disease and pneumonia in children in San José, Costa Rica
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Prospective epidemiologic surveillance of invasive pneumococcal disease and pneumonia in children in San José, Costa Rica
چکیده انگلیسی

BackgroundStreptococcus pneumoniae (SP) is the leading cause of vaccine-preventable death in children <5 years of age, globally. This surveillance determined incidence rates of invasive pneumococcal disease (IPD), clinical and chest radiograph-confirmed pneumonia (CXR + Pn); and SP serotype distribution and antimicrobial susceptibility in children in San José, Costa Rica.MethodsThis was a 2-year prospective, population-based surveillance conducted in 2007–2009 in children aged 28 days to 36 months presenting to participating healthcare centers. Eligibility criteria for study inclusion were as follows: temperature ≥ 39.0 °C within 24 h and/or clinical suspicion of IPD or pneumonia.Results8801 subjects were enrolled. Median age: 14.5 months. A total of 25 children had invasive pneumococcal disease with S. pneumoniae isolated from nonduplicative cultures (22) or detected solely by PCR and a clinical picture consistent with IPD (3). Sources of positive cultures (some children had >1 positive culture) were: blood (20), pleural fluid (4), and cerebrospinal fluid (3). Of the 3 cases detected solely by PCR, 2 were from cerebrospinal fluid and 1 from pleural fluid. The overall IPD incidence rates for culture-positive only cases for children aged 28 days to <3 years was 33.7/100,000 per year for years 1 and 2 combined. Age stratification of culture-positive only subjects showed a peak during year 1 (106.8/100,000) in children 28 days to <6 months of age group, and in year 2 (45.5/100,000) in children 12 months to <24 months of age group. Most common serotypes were 14 (28.6%), followed by 3, 4, 6A, 19A, and 22F (9.5% each). Of 22 nonduplicative IPD isolates, 42.9% were penicillin- and trimethoprim/sulfamethoxazole nonsusceptible isolates. Consideration of PCR-positive cases increases the incidence of IPD for children aged 28 days to <3 years to 46.0/100,000. Overall incidence of clinical pneumonia and CXR + Pn was 1968/100,000 and 551/100,000, respectively.ConclusionsThere is a considerable burden of IPD and pneumonia in children in San José. These epidemiologic data serve as a baseline to evaluate the effectiveness of the incorporation of new conjugate pneumococcal vaccines into the National Immunization Program in Costa Rican children.


► Prospective surveillance of pneumonia and IPD enhances disease burden estimates.
► Prospective data on incidence of IPD and pneumonia in Latin America are limited.
► Incidence of IPD and pneumonia in children was high in Costa Rica.
► Data represent only pediatric IPD active surveillance study from Central America.
► Surveillance is critical to assess impact of PCV vaccination.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 30, Issue 13, 16 March 2012, Pages 2342–2348
نویسندگان
, , , , , , , , , ,