کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2403600 | 1102918 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis A complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis](/preview/png/2403600.png)
Chikungunya virus, a mosquito-borne alphavirus, recently caused the largest epidemic ever seen for this virus. Chikungunya disease primarily manifests as a painful and debilitating arthralgia/arthritis, and no effective drug or vaccine is currently available. Here we describe a recombinant chikungunya virus vaccine comprising a non-replicating complex adenovirus vector encoding the structural polyprotein cassette of chikungunya virus. A single immunisation with this vaccine consistently induced high titres of anti-chikungunya virus antibodies that neutralised both an old Asian isolate and a Réunion Island isolate from the recent epidemic. The vaccine also completely protected mice against viraemia and arthritic disease caused by both virus isolates.
Journal: Vaccine - Volume 29, Issue 15, 24 March 2011, Pages 2803–2809