کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2403668 | 1102924 | 2012 | 8 صفحه PDF | دانلود رایگان |

In an effort to develop an effective and affordable oral vaccine against porcine Taenia solium cysticercosis, the S3Pvac anti-cysticercosis vaccine was expressed in papaya calli. Taenia pisiformis experimental rabbit cysticercosis was used as a model to compare the efficacy of the oral vaccine vs. the injectable S3Pvac-synthetic and S3Pvac-phage versions.Oral S3Pvac-papaya significantly reduced the expected number of hepatic lesions and peritoneal cysticerci to a similar extent than the injectable vaccines. This study reports for the first time an effective oral vaccine against T. pisiformis cysticercosis, possibly useful against porcine T. solium cysticercosis.
► S3Pvac synthetic, S3Pvac-phage, S3Pvac-papaya protects against rabbit cysticercosis.
► Parenteral S3Pvac induced high similar protection than oral S3Pvac-papaya vaccine.
► S3Pvac components are expressed in Taenia pisiformis cysticerci and in oncospheres.
► Vaccination increased the inflammatory reaction surrounding established cysticerci.
Journal: Vaccine - Volume 30, Issue 17, 5 April 2012, Pages 2760–2767