کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2404028 | 1102947 | 2010 | 12 صفحه PDF | دانلود رایگان |
The T-regulatory (T-reg) cells restrict the T-cell functions in various viral infections including influenza infection. However little is known about the effect of T-regs in influenza vaccination. Herein, we found that immunization of BALB/c mice with a prototype of UV-inactivated influenza PR8/A/34 virus vaccine expanded the CD4+Foxp3+ T-reg pool and fostered the development of virus-specific CD4+Foxp3+ T-reg cells. Increasing the size of Foxp3+ T-reg pool did not alter the primary PR8-specific B-cell response, but it did suppress the primary and memory PR8-specific T helper responses induced by vaccination. In contrast, the vaccination-induced T helper cell response was augmented in the absence of CD4+Foxp3+ T-reg cells. Since CD4 T helper cells contribute to anti-influenza protection, therapeutic “quenching” of T-reg function prior to vaccination may enhance the efficacy of influenza vaccination.
Journal: Vaccine - Volume 28, Issue 45, 21 October 2010, Pages 7319–7330