کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2404229 | 1102961 | 2009 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In silico DNA vaccine designing against human papillomavirus (HPV) causing cervical cancer
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In silico DNA vaccine designing against human papillomavirus (HPV) causing cervical cancer In silico DNA vaccine designing against human papillomavirus (HPV) causing cervical cancer](/preview/png/2404229.png)
چکیده انگلیسی
HPV vaccines available in the market are not effective against different strains of papillomavirus, therefore, there is a need to develop a new prophylactic DNA vaccine which can work against different strains of HPVs and may lead to protection of cervical cancer against new pandemic viruses. We designed a potential prophylactic DNA vaccine by using all the consensus epitopic sequences of HPVs L2 capsid protein and performed in silico cloning of multiepitopic antigenic DNA sequence in pVAX-1 vector. Immunogenicity of vaccine has been enhanced by techniques like codon optimization, engineering CpG motifs, introducing promoters and co-injection with plasmids expressing immune-stimulatory molecules.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 1, 10 December 2009, Pages 120–131
Journal: Vaccine - Volume 28, Issue 1, 10 December 2009, Pages 120–131
نویسندگان
Shishir Kumar Gupta, Archana Singh, Mugdha Srivastava, Shailendra K. Gupta, Bashir Akhlaq Akhoon,