کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2404428 | 1102975 | 2010 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Two distinct chimeric potexviruses share antigenic cross-presentation properties of MHC class I epitopes
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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![عکس صفحه اول مقاله: Two distinct chimeric potexviruses share antigenic cross-presentation properties of MHC class I epitopes Two distinct chimeric potexviruses share antigenic cross-presentation properties of MHC class I epitopes](/preview/png/2404428.png)
چکیده انگلیسی
Chimeric VLPs made of papaya mosaic virus (PapMV) trigger a CTL response through antigenic presentation of epitopes on MHC class I. Here, a chimeric VLP composed of malva mosaic virus (MaMV) was shown to share similar properties. We demonstrated the capacity of both VLPs to enter human APCs. The chimeric constructions were cross-presented in CD40-activated B lymphocytes leading to in vitro expansion of antigen-specific T lymphocytes. We showed that high concentrations of chimeric MaMV induced cell death, suggesting that some modifications can trigger collateral effects in vitro. Results suggest that potexvirus VLPs are an attractive vaccine platform for inducing a CTL response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 34, 2 August 2010, Pages 5617–5626
Journal: Vaccine - Volume 28, Issue 34, 2 August 2010, Pages 5617–5626
نویسندگان
Laïla-Aïcha Hanafi, Marilène Bolduc, Marie-Ève Laliberté Gagné, Florent Dufour, Yves Langelier, Mohammed-Rachid Boulassel, Jean-Pierre Routy, Denis Leclerc, Réjean Lapointe,