کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2404495 1102980 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of reattaching various Aeromonas salmonicida A-layer proteins on vaccine efficacy in Atlantic cod (Gadus morhua)
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Impact of reattaching various Aeromonas salmonicida A-layer proteins on vaccine efficacy in Atlantic cod (Gadus morhua)
چکیده انگلیسی

Atypical Aeromonas salmonicida causes atypical furunculosis in a whole range of farmed fish species. The bacterium comprises a heterogeneous group differing in surface components such as the A-layer protein and O-chain polysaccharide structures. Previously, the A-layer protein was shown to contribute to protective immunity as a vaccine with A. salmonicida cells with reattached A-layer protein protecting significantly better than the corresponding A-layer deficient bacteria used in the Atlantic cod (Gadus morhua) vaccine. In the present study, genetically different A. salmonicida A-proteins, either as preformed A-layer sheets from culture supernatants or as purified preparations, were shown to attach to A-layer deficient isolates with a different O-chain structure. Only vaccines containing A. salmonicida cells with reattached A-protein genetically homologous to the challenge isolate, elicited protection comparable to that of the homologous vaccine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 30, 5 July 2010, Pages 4703–4708
نویسندگان
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