کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2405148 1103017 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intradermal hepatitis B vaccination: A systematic review and meta-analysis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Intradermal hepatitis B vaccination: A systematic review and meta-analysis
چکیده انگلیسی

To compare seroprotection achieved by intradermal versus intramuscular hepatitis B vaccine, we conducted a systematic review of observational studies and a meta-analysis of randomized trials. Meta-analysis of data from 757 adults demonstrated that intradermal hepatitis B vaccination was slightly (14%) less likely to achieve seroprotection than intramuscular vaccination (risk ratiopooled 0.86; 95% confidence interval: 0.77–0.95). Diverse study methodologies detracted from our ability to synthesize data from these studies; standardized approaches would enhance comparability of future studies. Seroprotection from intradermal vaccination was higher among females and children, suggesting that these populations may be most appropriate for future intradermal vaccine development efforts.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 27, Issue 12, 13 March 2009, Pages 1777–1786
نویسندگان
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