کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2405666 1103044 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Further development of raccoon poxvirus-vectored vaccines against plague (Yersinia pestis)
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Further development of raccoon poxvirus-vectored vaccines against plague (Yersinia pestis)
چکیده انگلیسی

In previous studies, we demonstrated protection against plague in mice and prairie dogs using a raccoon pox (RCN) virus-vectored vaccine that expressed the F1 capsular antigen of Yersinia pestis. In order to improve vaccine efficacy, we have now constructed additional RCN-plague vaccines containing two different forms of the lcrV (V) gene, including full-length (Vfull) and a truncated form (V307). Mouse challenge studies with Y. pestis strain CO92 showed that vaccination with a combination of RCN-F1 and the truncated V construct (RCN-V307) provided the greatest improvement (P = 0.01) in protection against plague over vaccination with RCN-F1 alone. This effect was mediated primarily by anti-F1 and anti-V antibodies and both contributed independently to increased survival of vaccinated mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 2, 11 December 2009, Pages 338–344
نویسندگان
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