کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2405936 | 1103056 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Superiority of needle-free transdermal plasmid delivery for the induction of antigen-specific IFNγ T cell responses in the dog Superiority of needle-free transdermal plasmid delivery for the induction of antigen-specific IFNγ T cell responses in the dog](/preview/png/2405936.png)
SummaryAlthough successful needle-free DNA vaccination has been described on several occasions, the true benefit of this delivery technology over needle-based injections for DNA vaccination of dogs has not yet been documented. We conducted a side-by-side comparison of needle-free transdermal plasmid delivery vs. intramuscular vs. intradermal needle-based delivery of the same plasmid in dogs. Our data confirmed the importance of the route of plasmid delivery and further established the unique potential of needle-free transdermal plasmid delivery to elicit strong antigen-specific, hTyr-specific IFNγ T in the dog. Further, this study demonstrated that properly enabled DNA vaccination has the potential to trigger very significant cell-based immune responses in dogs, establishing needle-free transdermal plasmid delivery as a critical technology for successful immunotherapy of cancer and/or chronic infectious diseases in companion animal medicine.
Journal: Vaccine - Volume 26, Issue 18, 24 April 2008, Pages 2186–2190