کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2406057 1103061 2008 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The protective efficacy aganist Schistosoma japonicum infection by immunization with DNA vaccine and levamisole as adjuvant in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The protective efficacy aganist Schistosoma japonicum infection by immunization with DNA vaccine and levamisole as adjuvant in mice
چکیده انگلیسی

SummaryLevamisole (LMS) as an adjuvant enhances cell-mediated immunity in DNA vaccination; we investigated the efficacy and liver immunopathology alleviation of a DNA vaccine, VR1012-SjGST-32, in a LMS formulation in the murine challenge model. Compared to controls, the VR1012-SjGST-32 plus LMS can reduce worm and egg burdens, as well as, immunopathological complications associated chronic inflammation significantly in liver, which were apparently associated with Th1-type response. Together, these results suggest that the LMS as a potential Schistosome DNA vaccine adjuvant can enhance both worm killing and disease prevention, which is possibly mediated through the induction of a strong Th1-dominant environment in immunized mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 26, Issue 15, 28 March 2008, Pages 1832–1845
نویسندگان
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