کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2406842 1103098 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-term antibody persistence induced by a combined hepatitis A and B vaccine in children and adolescents
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Long-term antibody persistence induced by a combined hepatitis A and B vaccine in children and adolescents
چکیده انگلیسی

SummaryTwo cohorts, comprising of subjects aged 1–6 years and 6–15 years were vaccinated with Twinrix™ according to a 0-, 1- and 6-month schedule. The 1–6 years cohort was followed up for 7.5 years and the 6–15 years cohort for 10 years.At the latest follow-up time point, all subjects were seropositive for anti-HAV antibodies, while 86.5% (32/37) and 95.5% (21/22) had anti-HBs ≥ 10 mIU/ml in the 1–6 years and in the 6–15 years cohort. The geometric mean concentrations (GMCs; mIU/ml) were 233 and 680 for anti-HAV antibodies, and 147 and 165 for anti-HBs antibodies, in the 1–6 years and 6–15 years cohorts, respectively. The high persistence of circulating anti-HAV and anti-HBs antibodies in children and adolescents demonstrates the long-term protection offered by Twinrix™ in these age groups.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 26, Issue 14, 25 March 2008, Pages 1759–1763
نویسندگان
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